GitHub - Orama-Interactive/Pixelorama: Unleash your creativity with Pixelorama, a powerful and accessible open-source pixel art multitool. Whether you want to create sprites, tiles, animations, or just express yourself in the language of pixel art, this software will realize your pixel-perfect dreams with a vast toolbox of features. Available on Windows, Linux, macOS and the Web!
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Unleash your creativity with Pixelorama, a powerful and accessible open-source pixel art multitool. Whether you want to create sprites, tiles, animations, or just express yourself in the language o...

I posted here recently about Libresprite, a fork of the last FOSS release of Asesprite before they switched away from GPLv2.

However in the comments of that thread, @Tingly3771@beehaw.org mentioned Pixelorama as a more developed alternative.

I’d heard of it when it was released 5 years ago, but never looked into it until now. After testing it, I’m insanely impressed with not only how good the program is right now, but also with how fast development seems to be. There are a handful of things Aseprite does that Pixelorama doesn’t yet, but by the next major release, it should be at feature parity for the most part.

If you do pixel art at all, definitely worth checking out!