Compatible with Zigbee/Thread/Matter and Z-Wave Mixtile 2-in-1 Zigbee & Z-Wave mPCIe Interface Module is designed for Home Assistant users and developers. It offers easy connectivity with Zigbee and Z-Wave and will support Matter specifications with a future Mixtile firmware update. It supports Over-The-Wire (OTW) Firmware Update via the mini PCIe interface, which allows easy and quick firmware updates for both protocols. Mixtile 2-in-1 Zigbee & Z-Wave mPCIe Interface Module is compatible with any IoT gateway with mini PCIe interface and runs the Home Assistant. It also works seamlessly with our Mixtile Edge 2 Kit IoT gateway. * Shipped in a month.
Most people I know run it in a VM. I run it on Proxmox.