My experience trying it with 4 different cats for different issues is that Feliway rarely has any effect. YMMV, but the research on the subject seems to indicate that it’s mostly useless (unless the research is funded by the company that produces Feliway): https://whatyourcatwants.com/feliway

How feisty? You can search Amazon for “cat handling gloves” and find something that’s probably fine for a cat that just gets a little carried away while playing. A lot of them are basically just welding gloves. Some are modified with a little extra material in common bite zones. We have a long haired cat that absolutely hates being groomed. When handled too much she goes into full Pinky mode wherein she will dig in her claws and bite hard enough to cause permanent scarring (I know from experience). Unfortunately she needs regular grooming or she develops terrible matting. So I invested in a set of these: https://armorhandglove.com/

They weren’t cheap, but with those, she can bite as hard as she wants and I barely feel it.